The ovary: basic biology and clinical implications.

Survey on the interaction effect of dopamine D2 receptor antagonist on morphine-induced polycystic ovary syndrome in rat

Background and Objective: Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders in premenopausal women. Opioid drugs, including morphine are effective inducers of the PCOS. Hyperprolactinemia also increases the likelihood of this complication. The dopamine, the inhibitor of prolactin secretion, has receptors in the ovarian tissue. In this study, metoclopra...

A Study on the Effect of Cinnamon on the Structure of the Ovary in Diabetic Rats

Background & Aims: Diabetes mellitus influences the reproductive system. Since investigations have showed that cinnamon may have an improving effect on diabetes, this study was designed to investigate the effect of cinnamon extract on the ovary structure in diabetic rats. Methods: A total of 24 female wistar rats (186±15gr) were randomly divided into 4 equal groups of control, control + cinnamo...

Endothelial Progenitor Cell Dysfunction in Polycystic Ovary Syndrome: Implications for The Genesis of Cardiovascular Diseases

Pathological characteristics of uterus in rats with polycystic ovary

Background and Objective: Uterus of rat with polycystic ovary (PCO) may show pathological features. We provided pathological evidence for the rat uterus with NO-induced PCO.    Materials and Methods: Wistar rats (weighing 200-250 g) were kept diestrous to receive L-arginine (50 mg/kg) intraperitoneally (i.p.) for 9 days/once a day. Control group solely received saline (1 ml/kg, 9 days/once per ...

Protective Effect of Hydroethanolic Extract of Lippia citrodora L. Leaf and Vitamin D3 on Estradiol Valerate-Induced Polycystic Ovary Syndrome in Mice

Background and Objectives: This study was conducted to investigate the protective effect of hydroethanolic extract of Lippia citrodora L. leaf (LCE) and vitamin D3 on polycystic ovary syndrome (PCOS) in suri rats.   Methods: This experimental study was performed on 48 female suri rats with a weight range of 25-35g. The subjects were divided into 8 groups (n=6 each), namely control (food + wate...

Protective effect of silver nano particles against ovarian polycystic induced by morphine in rat

Background and Objective: Morphine can cause harmful effects in the ovaries. The silver nanoparticles (Ag-NPs) used in health care because of antimicrobial properties, can diffuse into the brain blood barrier. This study investigated the protective effect of Ag-NPs on the induction of polycystic ovary (PCO) due to injection of morphine intra-ventromedial hypothalamus (intra-VMH) of rat compared...